Predicting the effects of climate change on organismal fitness has been a focus of ecological research for decades. Freshwater fish are a group of particular concern because they are constrained in their ability to disperse and avoid unsuitable conditions. To effectively protect these sensitive species, it is imperative to understand the stressors that are putting them at risk. Prior studies have largely looked at one abiotic stressor and one species at a time; however, freshwater communities are made up of many species with multiple stressors that occur in tandem in the natural environment and are rarely experienced in isolation. The objective of this study is to quantify the net-effects of co-occurring stressors that fall within three categories: pollutants, thermal, and hydrologic stress. We conducted a review and meta-analysis to better understand how organisms respond to multiple simultaneous stressors. Our analysis revealed large gaps in available data, where many common stressors are understudied in multiple-stressor experiments. Most studies in our analysis (63%) tested a temperature x heavy metal interaction, with 22% of studies testing interactions between temperature x nutrients, and very few testing other stressor combinations. The diversity of taxa studied is also limited, with most being model or game fish species. Our review highlights the need for further research into the effects of multiple stressors, especially considering stressor type, taxa, life stage, and response variables. Identifying the strength and type of interaction (i.e., synergistic, antagonistic, additive) that multiple stressors have on organisms is also important, as it allows us to understand how current and projected environmental and anthropogenic stress will affect species’ ability to persist in certain areas and will help inform conservation efforts.