Per- and polyfluoroalkyl substances (PFAS) are a man-made class of fluorinated compounds that degrade under extreme heat and pressure, making them persistent pollutants in the environment. Wetlands are crucial ecosystems that filter nutrients and sediments, improving water quality, consequently leading to the retention of pollutants like PFAS. Wetland reptiles and amphibians are particularly vulnerable to PFAS exposure, given their proximity to these ecosystems. Here, I synthesize relevant literature to explore how PFAS exposure in wetlands influences the health and development of reptile and amphibian populations. Gray tree frogs are more sensitive to PFOS and PFOA at later developmental stages, while small-mouthed salamanders are more sensitive to PFOA at earlier stages, indicating species-specific toxicity. Furthermore, the review identifies a range of observed effects, including bioaccumulation, maternal offloading, endocrine disruption, developmental delays, growth alterations, immunosuppression, neurotoxicity, liver damage, organ and skeletal defects, mortality, metabolic disruption, DNA/RNA alterations, changes in snout-vent length, and alterations in scale mass index. My analysis highlights a disproportionate research focus on legacy PFAS (e.g., PFOS and PFOA) and the northern leopard frog, alongside a deficit in studies on wetland reptiles, particularly during early life stages. Understanding how PFAS impact species throughout their lifecycle is critical for informing conservation strategies for wetland reptiles and amphibians.