Corbicula fluminea (C. Fluminea) is a prolific species of freshwater clam that is highly invasive in North America. The natural history/behavior of C. Fluminea directly exposes them to harmful algal blooms (HABs) and their toxins. HABs are capable of negatively affecting water parameters and are considered environmental stressors. When present in freshwater environments, cyanotoxins such as microcystin or anatoxin can directly affect the physiology of C. Fluminea. C. Fluminea is frequently found in waters with high levels of pollution and/or algal toxins and has been used as a model organism for ecotoxicology studies. While the physiological responses of corbicula to toxicants are well-studied, little is known about the impacts on Corbicula microbiomes and host-microbe interactions. To address this knowledge gap, we have developed C. Fluminea as a model to study the impacts of harmful algal toxins in aquatic host-microbe systems. In initial baseline studies, we are determining tissue-specific microbiome variability in C. Fluminea and establishing an environmental time-series to determine exposure to HAB toxins and environmental impacts on the microbiome. Future laboratory studies will experimentally test the impacts of HABs on C. Fluminea microbiomes and physiology, examining both acute impacts and microbiome resilience.