Wetlands provide numerous ecosystem functions within their connected landscapes that improve water quality, including nutrient removal. Broad-scale loss of wetlands has removed landscape buffers to sources of nonpoint source pollution, such as nutrient-laden agricultural runoff, making downstream connected waters more susceptible to eutrophication and decreasing watershed resiliency. Due to growing recognition of the role of wetlands in maintaining downstream water quality, there is an increasing emphasis on identifying existing and potential wetlands for targeted management efforts (e.g., preservation and construction) as a strategy to buffer nonpoint source nutrient pollution within watersheds and improve water quality. We investigated the capacity of wetlands to intercept nutrients from agricultural runoff across the conterminous United States (CONUS) by identifying existing and potential wetlands lying on surface flow paths draining agricultural lands and developing a dataset of their delineated basins. We identified 2.3 million existing wetlands (256,360 km2) that intercept agricultural runoff and an additional 10.3 million parcels of potential wetland area (422,499 km2) that could be used to increase interception. These intercepting wetland areas, both potential and existing, lie on flow paths that drain 78% of all agricultural land cover, and their delineated basins drain 3,108,055 km2 (38%) of CONUS. Landscape characteristics of these delineated basins are being used to develop a framework to identify specific wetland areas that could support water quality management. Our framework will provide valuable insight for state and local managers to evaluate wetland implementation strategies to mitigate impacts of nonpoint source pollution across CONUS and improve water quality.